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Oxidative stress induced mitochondrial protein kinase A mediates cytochrome C oxidase dysfunction
Hypoxic environment characterized by low O2 tension is encountered by cells and tissues under many pathological conditions including ischemia, inflammation, skeletal-muscular disorders, and solid tumors. A large part of respired O2 in metazoan organisms is utilized by mitochondria in processes directly linked to oxidative phosphorylation.
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