Environmental Factors Related to Multiple Sclerosis in Indian Population

Citation: Malli C, Pandit L, D’Cunha A, Mustafa S (2015) Environmental Factors Related to Multiple Sclerosis in Indian Population. PLoS ONE 10(4): e0124064. doi:10.1371/journal.pone.0124064
Published: April 22, 2015

MS_DemyelinisationBackground: Multiple sclerosis (MS) is less prevalent among Indians when compared to white populations. Genetic susceptibility remaining the same it is possible that environmental associations may have a role in determining disease prevalence.
Aims: To determine whether childhood infections, vaccination status, past infection with Helicobacter pylori (H.pylori), diet, socioeconomic and educational status were associated with MS.
Material and Methods: 139 patients and 278 matched control subjects were selected. A validated environmental exposure questionnaire was administered. Estimation of serum H.pylori IgG antibody was done by ELISA. Patients and controls were genotyped for HLA-DRB1*15:01.
Results: In our cohort a significant association was seen with measles (p <0.007), vegetarian diet (p < 0.001, higher educational status (p <0.0001) and urban living (p <0.0001). An inverse relationship was seen with H.Pylori infection and MS (p <0.001). Measles infection (OR 6.479, CI 1.21- 34.668, p< 0.029) and high educational status (OR 3.088, CI 1.212- 7.872, p< 0.018) were significant risk factors associated with MS. H.pylori infection was inversely related to MS (OR 0. 319, CI 0.144- 0.706, p <0.005).
Conclusions: Environmental influences may be important in determining MS prevalence.


Log in or register for free to continue reading
Register Now For Free Already Registered? Log In
This entry was posted in Neurology, Primary Care and tagged .

Post a Comment

You must be logged in to post a comment.