Continuous intestinal infusion of levodopa-carbidopa gel shows benefit in advanced Parkinson’s disease

mdCurrent Conference Report: 64th American Academy of Neurology Annual Meeting

A novel strategy to reduce the motor complications associated with fluctuating blood levels of levodopa in patients with Parkinson’s disease was associated with clinically meaningful improvements in disease control, according to the authors of a double-blind trial.

Undertaken in patients with advanced disease with substantial previous exposure to levodopa and long off times, the study compared a continuous infusion of levodopa-carbidopa intestinal gel (LCIG) delivered by a percutaneous intrajejunal gastrostomy tube to standard immediate-release oral therapy.

Compared to standard treatment, LCIG reduced off time by 1.91 hours (P=0.0015) at the end of the 12-week study, according to data presented at the 64th Annual Meeting of the American Academy of Neurology in New Orleans, Louisiana, United States. The baseline mean off time was...

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This entry was posted in mdCurrent Conference Reports, Neurology, Pharmacology and tagged , , , , , , . Volume: .

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