Could a rotavirus vaccine based on genotypes prevalent in India be on the horizon?

Rotavirus is a leading cause of severe infant diarrhea, causing an estimated 100,000 deaths each year in India, according to the World Health Organization. While most young children in the world contract rotavirus at some point in their early childhood, the disease course is usually much more severe for children in developing countries, including India.

“…Pediatricians should honestly inform the parents about the efficacy of the vaccine in developing countries like Bangladesh and allow the parents to make an informed choice.”
-D.K. Taneja, MD, vice president of the Indian Public Health Association and director/professor of Community Medicine at Maulana Azad Medical College in New Delhi, India

A recently published review article highlighted the burden of rotavirus in India. The authors noted that although the virus is transmitted through a feco-oral route, widespread improvements in sanitation have done little to halt its spread.

A rotavirus vaccine is available, which has been launched in 62 countries and has been added to the national immunization schedule in 11. In India, the vaccine...

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