Tobacco use or body mass – Do they predict tuberculosis mortality in Mumbai, India?

Results from a population-based cohort study

Citation: Pednekar MS, Hakama M, Gupta PC (2012) Tobacco Use or Body Mass – Do They Predict Tuberculosis Mortality in Mumbai, India? Results from a Population-Based Cohort Study. PLoS ONE 7(7): e39443. doi:10.1371/journal.pone.0039443
Published: July 27, 2012

AbstractCloseup of smoking tobacco
Tobacco use and under-nutrition are major public health concerns and tuberculosis is a major cause of morbidity and mortality in India. Using a cohort of 148,173 persons (recruited 1991–1997 and followed-up 1997–2003) the joint effects of tobacco use and BMI on tuberculosis mortality was studied. Tobacco use in any form and low-BMI had joint effect on tuberculosis mortality and the interaction effect was synergistic in men and antagonistic in women. Self-reported tuberculosis was associated with increased risk of tuberculosis mortality. In contrast, no such association was observed for self-reported diabetes persons. The risk pattern remained unchanged even after excluding tuberculosis deaths occurred within 1st two years of follow-up. This study highlights importance of age consideration of individual while excluding early deaths. Around 27% male tuberculosis deaths were attributable to their being underweight and smoker, while 22% male and 37% female deaths were attributable to their being underweight and smokeless tobacco user.

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