Category Archives: Cardiovascular

Global cardiovascular research output, citations, and collaborations

Economic development has been associated with transitions in health, notably shifts from communicable diseases to non-communicable, chronic diseases [NCDs] including cardiovascular diseases [CVD] [1]. Health research is one mechanism to improve population-level health and should generally match the health needs of populations.

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Sympathovagal imbalance contributes to prehypertension status and cardiovascular risks attributed by insulin resistance, inflammation, dyslipidemia and oxidative stress in first degree relatives of type 2 diabetics

Recently it has been reported that Asian Indian phenotype is exceptionally predisposed to develop diabetes because of strong familial aggregation and abrupt change in lifestyle [1]. As reported by World Health Organization (WHO), the total number of diabetic population was 171 million in 2000, which is projected to rise up to 366 million in 2030 [2].

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The correlates of body composition with heart rate recovery after step test

Heart rate recovery (HRR) is the rate where the heart beat declines to resting levels after an exercise is performed [1]. HRR is mediated by the autonomic nervous system (ANS), with the rate in the early phase being controlled by the parasympathetic reactivation and later by the withdrawal of sympathetic activity [2-5].

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Should physical activity recommendations be ethnicity-specific?

Two of the major modifiable risk factors for type 2 diabetes and cardiovascular disease are obesity [1], [2] and a low level of physical activity [3], [4]. Because of this, national and international bodies have made recommendations regarding appropriate levels for body mass index (BMI) [5], waist circumference [5], and physical activity [6]–[8], to minimise risk of vascular and metabolic disease.

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The effectiveness of a ‘Train the Trainer’ model of resuscitation education for rural peripheral hospital doctors in Sri Lanka

Resuscitation education is an emerging field in Sri Lanka, run largely by consultant anaesthetists working at tertiary referral centers and the larger secondary hospitals. The heavy workload of these specialists limits the opportunity to provide training to rural peripheral hospital doctors. Previous research has identified that rural peripheral hospital doctors feel professional isolation due to a lack of training opportunities [1].

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Oxidative stress induced mitochondrial protein kinase A mediates cytochrome C oxidase dysfunction

Hypoxic environment characterized by low O2 tension is encountered by cells and tissues under many pathological conditions including ischemia, inflammation, skeletal-muscular disorders, and solid tumors. A large part of respired O2 in metazoan organisms is utilized by mitochondria in processes directly linked to oxidative phosphorylation.

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Curcumin suppresses gelatinase B mediated norepinephrine induced stress in H9c2 cardiomyocytes

The catecholamines, Epinephrine and Norepinephrine (NE), have been demonstrated to pose stress conditions on the cardiac cells deteriorating their structure and function [1]. NE, an adrenergic agonist has been shown to induce stress on the heart with and without adrenoreceptor blockade even in micromolar concentrations [2].

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