Tag Archives: mycobacterium tuberculosis

Field Evaluation of a Blood Based Test for Active Tuberculosis in Endemic Settings

Mycobacterium tuberculosis (M. tb.), the etiologic agent of tuberculosis, is one of the most successful human pathogens on the planet. Approximately two billion people are infected with M. tb. worldwide…

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Mycobacterium tuberculosis DevR/DosR Dormancy Regulator Activation Mechanism

Two component systems permit bacteria to sense and adapt to diverse environmental stresses. The DevR-DevS TCS (also called DosR-DosS) is one of the best characterized TCS of Mycobacterium tuberculosis…

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A Web-Based Platform for Designing Vaccines against Existing and Emerging Strains of Mycobacterium tuberculosis

The tuberculosis cost millions of lives every year globally as well as billions of humans are infected with this deadly disease. In addition, treatment is not patient friendly, as it requires combination of drugs for…

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High Rates of Ofloxacin Resistance in Mycobacterium tuberculosis among Both New and Previously Treated Patients in Tamil Nadu, South India

Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major public health issue in most of developing countries, despite scaling up interventions to achieve global control [1]. The risk of progression of TB is enhanced by human immunodeficiency virus (HIV) infection and malnutrition, especially…

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Mycobacterium tuberculosis Modulates the Gene Interactions to Activate the HIV Replication and Faster Disease Progression in a Co-Infected Host

Mycobacterium tuberculosis (Mtb) continues to be one of the most dreaded pathogens around the world and its co-habitation with HIV in a common host fuels both the infections. Of the estimated 39 million people living with HIV, about one-third are estimated to have concomitant latent tuberculosis (Global Tuberculosis Control, WHO, 2010). Depending on the prevalence of HIV…

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Low amounts of winter sunshine are associated with increased tuberculous meningitis incidence

Key Point: This study found a significant association between the monthly tuberculous meningitis incidence rate (a severe extrapulmonary complication of TB) and the number of sunshine hours 3 months earlier–possibly implicating vitamin D deficiency. Tuberculous meningitis (TBM) is a severe extrapulmonary complication of tuberculosis occurring mainly in early childhood, and… 

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