Tag Archives: miltefosine

Safety and Efficacy of Short Course Combination Regimens with AmBisome, Miltefosine and Paromomycin for the Treatment of Visceral Leishmaniasis in Bangladesh

Before the introduction of single-dose AmBisome, miltefosine was included in the National Guidelines of India, Nepal and Bangladesh as a first line treatment for VL following a phase III trial in India that showed a final cure rate of 94%. However, poor compliance due to…

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Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum

Depending on the geographical location, visceral leishmaniasis can either be caused by Leishmania donovani (East Africa and Indian subcontinent) or L. infantum (Mediterranean basin, central Asia and Latin America). Although both species are closely related and belong to the same complex (L. donovani complex), transmission of L. donovani is mostly anthroponotic while…

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