Tag Archives: leishmania donovani

A GCN2-Like eIF2α Kinase (LdeK1) of Leishmania donovani and Its Possible Role in Stress Response

Leishmania spp. are protozoan parasites belonging to the family trypanosomatidae and are the causative agent of leishmaniasis. Among the various clinical forms of leishmaniasis that exist, the visceral leishmaniasis (VL) is the most…

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Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation

Leishmaniasis is a vector borne disease caused by a digenetic parasite of genus Leishmania. There are few drugs available in the market against leishmaniasis, but they have many limitations, like drug resistance, toxicity, high…

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Induction of IL-10 and TGFβ from CD4+CD25+FoxP3+ T Cells Correlates with Parasite Load in Indian Kala-azar Patients Infected with Leishmania donovani

Visceral leishmaniasis (VL) or kala-azar, a deadly infection affecting the organs of lymphoreticular system, is caused by the protozoan parasites of the Leishmania donovani complex. Human infections can be…

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Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

VL is the second most important vector-transmitted protozoa disease, second only to malaria and an important opportunistic infection in patients with HIV. Its main clinical signs in humans and dogs are hypergammaglobulinaemia, hepato-splenomegaly…

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Heterogeneity of Leishmania donovani Parasites Complicates Diagnosis of Visceral Leishmaniasis

Visceral leishmaniasis (VL) is a serious health problem in various countries and is caused by parasites belonging to the Leishmania donovani complex comprising two major subspecies, L. infantum mainly occurring in…

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Leishmania donovani Infection Enhances Lateral Mobility of Macrophage Membrane Protein Which Is Reversed by Liposomal Cholesterol

The protozoa parasite, Leishmania donovani, (LD) replicates within the macrophage of the mammalian host [1]. The parasite during their intracellular life cycle causes wide variety of defects in cellular physiology like decrease in membrane cholesterol [2] with concomitant increase in membrane fluidity [3]. LD infectedmacrophage are unable to stimulate antigen specific T cells [3] and…

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Seasonal variation in the prevalence of sand flies infected with Leishmania donovani

In vector borne diseases, the seasonality of the vector species directly affects the transmission of the infectious disease. Thus, the study of insect behaviour in natural settings is crucial to understanding the current status of any disease.

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