Screening using flexible sigmoidoscopy significantly reduced the incidence of colorectal cancer and mortality, according to a recently published large prospective randomized study. Overall, colorectal cancer mortality was reduced by 26% in patients assigned to sigmoidoscopy (2.9 vs 3.9 deaths per 10,000 person-years) in the study. A 50% reduction in death…
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Cancer rates are on the rise worldwide and predicted in a recent study to increase by 75% to an estimated 22.2 million new cancer cases in 2030, compared with 12.7 million in 2008. In countries such as India, new cancer cases are predicted to rise slightly higher to 78%, while…
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A comprehensive review of several medical groups’ guidelines for colorectal screening has resulted in a new guidance statement that includes a number of useful recommendations. Key Point: The ACP’s critical review of multiple guidelines offers guidance regarding colorectal cancer screening. In searching the National Guidelines Clearinghouse developed in the United…
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Two new studies confirm the value of colonoscopy in detecting advanced colorectal cancer and reducing mortality. Key Point: Colonoscopy is an effective screening test for detecting adenomas and reducing mortality from colorectal cancer. Fecal immunochemical testing is not an adequate substitute for colonoscopy. You should recommend screening colonoscopies to your…
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Fish oil suppresses cell growth and metastatic potential by regulating PTEN and NF-κB signaling in colorectal cancer
Epidemiological reports have shown that the incidence of cancer is increasing worldwide [1]. Cancer is the disease in which there is a deregulation of cell proliferation and cell death. In cancerous cells, endogenous signal transduction pathways get disturbed to redirect the cellular decisions from differentiation and apoptosis to proliferation and, later, invasion [2].
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