Metabolic syndrome associated with all-cause mortality in older women, but not older men

The presence of metabolic syndrome is associated with all-cause mortality in women aged 70 to 79 years, while no significant risk was found in similarly aged men. This was the finding of a recent cohort study that sought to determine the association of metabolic syndrome with all-cause mortality in older adults.

Metabolic syndrome is a constellation of abnormalities associated with increased cardiovascular disease (CVD). It is predicted that by[s2If !is_user_logged_in()]…

[/s2If][s2If is_user_logged_in()] 2020, an estimated 2.6 million Indians will die of CVD, and CVD will be the leading cause of disability and death in the country (Cholesterol. 2011;2011:1-7).

In the recently published study, residents of 2 provinces in Italy who were at least 65 years of age were enrolled. Researchers obtained demographic and laboratory information to determine if patients had metabolic syndrome. Four well-accepted definitions were used, all of which included parameters for abdominal obesity, hyperglycemia, hypertriglyceridemia, low density lipoprotein, and hypertension. Separate models were run for men and women.

Key Point: The presence of metabolic syndrome increases a 70- to 79-year-old woman’s risk of all-cause mortality by about 50%, while there is no significant association in men. It’s important to counsel patients to prevent the chronic diseases that lead to metabolic syndrome and to diagnose the condition early if it does occur, so that lifestyle and pharmacologic interventions can occur.

Over a mean follow-up of 6.5 years, 179 and 193 deaths occurred in women and in men, respectively. Regardless of the definition used, women diagnosed with metabolic syndrome had an increased risk of mortality (hazard ratio ranges were 1.50-1.72). However, when stratified by age, the risk remained elevated only in the subgroup of women aged between 70 and 79 years. Metabolic syndrome was not associated with all-cause mortality in men, regardless of definition or age stratification.

Hyperglycemia also was found to increase a woman’s risk of death (HR 1.48), while hypertriglyceridemia (HR 1.62) and low high-density lipoprotein (1.56) each increased a man’s risk of death.

Results were adjusted for age, education, cohort of origin, smoking status, alcohol intake, sedentary lifestyle, body mass index, pre-existing major diseases, use of statins, total cholesterol, and high C-reactive protein.

Source: Forti P, Pirazzoli G, Maltoni B et al. Metabolic syndrome and all-cause mortality in older men and women. Eur J Clin Invest. 2012 [epublication ahead of print].

Sawant A, Mankeshwar R, Shah S et al. Prevalence of metabolic syndrome in Urban India. Cholesterol. 2011;2011:1-7.

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This entry was posted in Geriatrics, Non-Communicable Disease, Primary Care, Women's Health and tagged , , , , , , , , , , . Volume: .

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