Low levels of plasma vitamin B6 are associated with systemic markers of inflammation

Low levels of pyridoxal-5-phosphate (PLP), the active form of vitamin B6, have been measured in patients with cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes.

Key Point: This study supports the hypothesis that inflammation is associated with a functional deficiency of vitamin B6. It is important to note that although the authors of this study report that PLP levels (the active form of vitamin B6) are lower in patients with elevated generalized inflammation, more studies are needed to determine whether low B6 levels actually cause inflammation.

In a recent study published in the Journal of Nutrition, investigators in the United States measured PLP levels in 2,229 participants (55% women, mean age 61 ±9 years) and analyzed their association with markers of generalized inflammation. The authors reported a statistically significant inverse relationship between PLP levels and several markers of inflammation. The results warrant further investigation into the underlying mechanisms—and the potential health consequences—of this correlation.

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This entry was posted in Cardiovascular, Nutrition, Nutrition Featured 2, Primary Care and tagged , , , , , , , , , , , , , , . Volume: .

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