CT colon screening without bowel prep IDs adenomas 10 mm and larger

Computed tomographic colonography (CTC) without bowel preparation correctly identified more than 90% of adenomas ≥10 mm in a recent multicenter study.

Key Point: Laxative-free colonography is accurate at detecting adenomas 10 mm and larger but is less reliable for detecting smaller lesions. Most polyps that affect survival are 10 mm and larger. This diagnostic test may be an option for patients who otherwise might opt out of preventive colon screenings due to an aversion to laxative preparations.

While rates of colorectal cancer tend to be higher in developed countries than they are in India, population-based trend studies have demonstrated a rising incidence in diagnosis, according to a 2008 study in the Asian Pacific Journal of Cancer Prevention.

The investigators for the recent study assessed 605 patients aged 50 years to 85 years who were at average to moderate risk of colon cancer. Patients who were part of the clinical trial, which was conducted in the United States, were screened with CTC without the use of laxatives. Instead, an oral contrast agent was used and feces were subtracted from the scan digitally.

Five weeks later, the patients underwent traditional optical colonoscopy. The sensitivity for detecting adenomas 10 mm or larger was not significantly different between CTC (91%) and optical colonoscopy (95%). For adenomas <6 mm, however, optical colonoscopy was...

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