Clopidogrel plus aspirin can cause more harm than good in small subcortical stroke prevention

Adding clopidogrel to aspirin as an anti-blood clot regimen is unlikely to prevent recurrent small subcortical strokes and also may increase the risk of bleeding and death in patients with subcortical stroke (S3), according to a recent study that investigators stopped early due to these findings.

Key Point: Adding clopidogrel 75 mg/day to aspirin 325 mg/day as an anti-blood clot regimen in stroke patients is unlikely to decrease S3 stroke recurrence and also puts patients at a higher risk of bleeding or death compared with aspirin therapy alone. Combination therapy is not recommended.

Researchers reported the results of the anti-clotting portion of the Secondary Prevention of Small Subcortical Strokes Trial (SPS3) at the American Stroke Association’s International Stroke Conference 2012. SPS3 specifically examined the use of 325 mg/day of therapeutic aspirin alone or in combination with 75 mg/day of clopidogrel to prevent the recurrence of S3, which occur when small blood vessels deep in the brain are blocked and damage small areas of brain tissue. Even though S3 are common, this was the first large-scale study of patients with...

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This entry was posted in Hypertension, Neurology, Non-Communicable Disease, Pharmacology, Primary Care and tagged , , , , , , , , , , , , , . Volume: .

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