Circumcised men have less prostate cancer

Men who are circumcised before their first sexual intercourse have a lower risk of both less aggressive and more aggressive forms of prostate cancer compared with uncircumcised men.

The authors, from the University of Washington, Seattle, United States, write that the data support both inflammation and infection in the prostate as prostate cancer etiologies, which has been suspected from previous findings.

They analyzed data from 2 population-based case-control studies involving 1,754 men with prostate cancer and 1,645 controls. Participants reported their[s2If !is_user_logged_in()]…

[/s2If][s2If is_user_logged_in()] circumcision status, age at circumcision, age at first sexual intercourse, history of sexually transmitted infections, and history of prostatitis.

Key Point: By reducing the risk of infection and subsequent inflammation, both of which may play a role in the development of prostate cancer, circumcision may also reduce the risk of prostate cancer.

Some 64.5% of the patients diagnosed with prostate cancer and 69% of the controls underwent circumcision before their first sexual intercourse, corresponding to a 15% reduction in the circumcised men.

When analyzed by prostate cancer aggressiveness (with an aggressive cancer defined as one with a Gleason score ≥7, a nonlocalized stage at diagnosis, or a prostate-specific antigen level >20 ng/mL), circumcised men had a lower prevalence of both less aggressive (odds ratio: 0.88) and more aggressive (odds ratio: 0.82) forms of prostate cancer.

Various studies have estimated that about between 8% and 13% of men in India are circumcised (http://www.circs.org/). A 2004 study in Mumbai, India, found that statistically, 1 out of 59 men there will be diagnosed with prostate cancer during his lifetime, with 99% of the diagnoses occurring after the age of 50 (Asian Pac J Cancer Prev. 2004;5(4):401-405).

Source: Wright JL, Lin DW, Stanford JL. Circumcision and the risk of prostate cancer. Cancer. Online before print. doi: 10.1002/cncr.26653.

Access the original journal information here:
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Cancer%22%5BJour%5D+AND+2012%5Bpdat%5D+AND+circumcision&TransSchema=title&cmd=detailssearch
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This entry was posted in Oncology, Primary Care, Urology and tagged , , , , , , , . Volume: .

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