Adequate folic acid and vitamin B12 intake could help reduce vascular disease risk in Indian patients

Elevated plasma homocysteine levels (hyperhomocysteinemia) are increasingly considered to be an important marker for cardiovascular disease (CVD), especially in Indians. The relevance of this finding is highlighted by reports that suggest mortality attributable to CVD is rising in India—and is expected to continue to rise—by 103% in men and by 90% in women from 1985 to 2015.

Key Point: Elevated plasma homocysteine levels are an important marker for cardiovascular disease, especially in Indian patients. Homocysteine concentrations negatively correlate with folate and vitamin B12 levels. Therefore, modulating their intake could help reduce the incidence and morbidity of vascular disease.

In a recently published study conducted by researchers at the Sir Ganga Ram Hospital and the Jamia Millia Islamia in New Delhi, India, plasma homocysteine concentrations were shown to have a significant, negative correlation with vitamin B12 levels in patients with cerebrovascular and peripheral vascular disease, and with folate (vitamin B9) levels in patients with coronary artery and cerebrovascular disease.

Homocysteine metabolism is dependent on...

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