Primary Care Articles

Increasing risk of cataract in HCV patients receiving anti-HCV therapy

Cataract, which has an estimated prevalence of 33% in the general population, is the second leading cause of visual impairment and vision loss worldwide. Cataract is associated with increasing Read more »

Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects

The iridocorneal endothelial syndrome is a disease spectrum which includes Chandler syndrome, Progressive iris atrophy and Cogan-Reese syndrome. The clinical variants are distinguished primarily on the basis of the changes in the iris. Progressive or... Read more »

Association of Hip Bone Mineral Density and Body Composition in a Rural Indian Population

Hip bone mineral density is a predictor of overall risk of fractures in later life. Body mass is one of the... Read more »

Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-Analysis

Chronic glaucoma is one of the most frequently established diseases in ophthalmology and represents a growing public health concern, with consequences that lead to blindness... Read more »

Increased Incidence of Thyroid Disease in Patients with Celiac Disease: A Systematic Review and Meta-Analysis

Celiac disease is an autoimmune disorder disease characterized by chronic inflammation and villous atrophy of the small intestine. This disease is caused by the ingestion of gluten-containing foods and other environmental factors. As... Read more »

Optical Coherence Tomographic Features and Prognosis of Pneumatic Displacement for Submacular Hemorrhage

Submacular hemorrhage can cause deterioration of visual acuity, and this occurs suddenly and often irreversibly in exudative age-related macular degeneration and polypoidal choroidal vasculopathy... Read more »

The Role of Physics and Engineering in Surgery

The Lancet commission on global surgery estimates that about one third of global disease burden is surgical. Many innovations like discovery of anesthesia, antisepsis helped surgeries take... Read more »

A High Level of Soluble CD40L Is Associated with P. aeruginosa Infection in Patients with Cystic Fibrosis

Cystic fibrosis (CF) is one of the most common inherited diseases resulting in a shortened life span. It affects approximately 70,000 people worldwide. CF is an autosomal recessive disease that is caused by mutations in... Read more »

The Combined Effect of High Ambient Temperature and Antihypertensive Treatment on Renal Function in Hospitalized Elderly Patients

Elderly people (over 65 years old) are more susceptible to environmental influences on their health including dehydration. Since aging is associated with several physiological and pathological processes, advanced age is... Read more »

A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men

Genetic predisposition plays a major role in susceptibility to alcoholism or ethanol-induced organ damage. Many association studies have been conducted to... Read more »

Involvement of Renin-Angiotensin System in Retinopathy of Prematurity – A Possible Target for Therapeutic Intervention

Renin Angiotensin System is the potent mechanism involved in the homeostatic control of arterial pressure, tissue perfusion, and extracellular volume. The key initiator molecule of this system-renin is... Read more »

Outcomes of Cataract Surgery in Urban and Rural Population in the South Indian State of Andhra Pradesh

Cataract remains the leading cause of visual impairment worldwide though proportions vary across regions. Cataract surgery is one of the most... Read more »

Managing Ureteric Calculi with Obstruction and Hydronephrosis in Rural Areas

Ureteric calculi are common and present often to the rural surgeon. The incidence is about 200 per 100,000 population and the trend is that it is increasing... Read more »

Xenobiotic Metabolism and Gut Microbiomes

Advancements in medicine as well as health care, along with increasing awareness of health and hygiene have resulted in a significant rise in the demand and consumption of... Read more »

Further Experience with Extraperitoneal LSCS

After initial experience they now have a longer blue colored Prolene in... Read more »

Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression

Pregnane and Xenobiotic Receptor, acts as a ‘master-regulator’ of expression of components of the detoxification machinery thereby defending the body from the toxic chemical insults... Read more »

Effect of Preoperative Risk Group Stratification on Oncologic Outcomes of Patients with Adverse Pathologic Findings at Radical Prostatectomy

Prostate cancer (PC) has become the most common non-dermatologic cancer among Western men. Due to prostate-specific antigen screening efforts, increasing numbers of PC cases are diagnosed when the tumor is still confined to... Read more »

Urology Emergencies for Rural Surgeons: Presented at the ARSI Conference at Kulu, November 2016

Unlike the other surgical specialties’ Urology does not have too many emergencies? Hence most of the Urologists do not plan for emergencies and the emergencies are left to the general... Read more »

Comparative Assessment of Vitamin-B12, Folic Acid and Homocysteine Levels in Relation to p53 Expression in Megaloblastic Anemia

Megaloblastic anemia (MBA), also known as macrocytic anemia, is characterized by decreased number of RBCs as well as the presence of unusually large, abnormal and poorly developed erythrocytes (megaloblasts), which fail to... Read more »

Differential Expression of Stem Cell Markers in Ocular Surface Squamous Neoplasia

Ocular surface squamous neoplasia (OSSN) is the most common tumor of the ocular surface with an estimated incidence 0.02 to 3.5 cases per... Read more »

Treatment Contact Coverage for Probable Depressive and Probable Alcohol Use Disorders in Four Low- and Middle-Income Country Districts

Mental, neurological and substance use disorders are the fifth-leading cause of disability-adjusted life years, with up to 3.8% of the global burden attributed to depression and... Read more »

PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide

PI3K is crucial signal transducing enzyme regulating cell proliferation, cell survival, differentiation, apoptosis and angiogenesis. It is essential for activation of AKT which plays a central role in both physiological and... Read more »

Establishment of 3D Co-Culture Models from Different Stages of Human Tongue Tumorigenesis: Utility in Understanding Neoplastic Progression

All normal tissues rely on a continuous sequence of cellular interactions in a microenvironment comprising several growth factors, hormones, adhesion molecules and an intricate extracellular molecular matrix for their growth and maintenance... Read more »

A Novel Homozygous Mutation in FOXC1 Causes Axenfeld Rieger Syndrome with Congenital Glaucoma

Anterior segment dysgenesis disorders encompass a wide variety of developmental conditions in which multiple tissues such as the cornea, iris, and lens are affected... Read more »

Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence

Oral cancer is lethal and usually causes spacious impairment to the organs involved including lesions of lip, tongue, major salivary glands, gums and adjacent oral cavity tissues... Read more »

HMGB1 May Be a Biomarker for Predicting the Outcome in Patients with Polymyositis/Dermatomyositis with Interstitial Lung Disease

Polymyositis and Dermatomyositis are heterogeneous complex autoimmune diseases that primarily target skeletal muscles and skin. They are characterized by... Read more »

Prostate Surgeries in Rural Areas

The prostate gland is a male sexual organ that contributes the bulk of secretions during sexual intercourse. It is situated near the junction of the urinary bladder with the urinary passage called... Read more »

What Is New About Appendix Surgeries?

Appendicectomy, also called appendectomy, is one of the most commonly performed surgeries, all over the world. The appendix is a vestigial organ in the human intestine, and it is prone to inflammation. The first successful operation was carried out by Claudius Aymand in 1735 (1). Most people never have any...  Read more »

How Targeted Biopsy Improves Prostate Cancer Diagnosis and Treatment [video]

When William Armstrong's PSA level numbers continually increased over the span of several years, he chose to ignore the numbers and not think about cancer. After seeing Stanford physicians Armstrong realized the possibility of prostate cancer had grown quite real and chose to take an aggressive approach to treat the...  Read more »
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