Risk of postnatal fever with misoprostol linked to dosage, administration route

The prostaglandin E1 analog misoprostol is widely used to prevent postpartum hemorrhage, which is the leading cause of maternal death in India. Misoprostol is especially practical in low-resource settings because of its efficacy, cost-effectiveness, and ease of administration (sublingual, oral, vaginal, or rectal). It’s also not heat labile, which makes it easy to store and administer.


“Fever can be a side-effect associated with misoprostol use. However, this may be minimized by rectal administration of the medication and should not be a deterrent to its use in low-resource settings for prevention of postpartum hemorrhage.”
-Jeffrey Chapa, MD, member of mdCurrent’s Global Editorial Advisory Board


While misoprostol in general has a positive safety profile, misoprostol-induced fever has been known to...

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This entry was posted in Ob/Gyn, Pharmacology and tagged , , , , , , . Volume: .

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