Infectious Disease Articles

Characterizing Antibody Responses to Plasmodium vivax and Plasmodium falciparum Antigens in India Using Genome-Scale Protein Microarrays

The burden of malaria in India has halved over the last 15 years, yet India continues to account for over 70% of malaria cases in South East Asia. The ‘National Framework for Malaria Elimination in India 2016–2030’ has two aims: eliminating malaria throughout the country by... Read more »

Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India

Visceral leishmaniasis is a vector-borne protozoal disease caused by the Leishmania donovani species complex. Estimated 200,000–400,000 new cases are recorded per year worldwide of which 67% of the total cases are contributed by three Asian countries... Read more »

Comparison of TST and IGRA in Diagnosis of Latent Tuberculosis Infection in a High TB-Burden Setting

According to the World Health Organization Global TB report, 2015 approximately one- third of the world population is infected with Mycobacterium tuberculosis. Although individuals with LTBI are asymptomatic, however, they constitute an important... Read more »

Molecular Mimicry between Chikungunya Virus and Host Components: A Possible Mechanism for the Arthritic Manifestations

Chikungunya fever is caused by a arbovirus belonging to Family Togaviridae and Genus Alphavirus. CHIKV is positive sense RNA virus with about 11.8 kb long genome. The prevalence of CHIKV has increased globally. It caused massive outbreaks when... Read more »

Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model

The number of available or prospective drugs for treating tuberculosis (TB) is undergoing a long-overdue expansion. Delamanid and bedaquiline, both recently approved for the treatment of multidrug-resistant TB, are the first novel agents registered for TB treatment in... Read more »

Widespread fear of dengue transmission but poor practices of dengue prevention

Dengue is an infectious viral disease transmitted by a domesticated mosquito, Aedes aegypti. There are supposedly 50 to 400 million people infected each year by dengue virus, developing various clinical spectrum of dengue infection that includes... Read more »

Gender Differences in Factors Related to HIV Risk Behaviors among People Who Inject Drugs in North-East India

Injection drug use is an important driver of HIV epidemics in different regions of the world including India, which is home to 168,000–1.1 million people who inject drugs with a high prevalence of HIV and... Read more »

Control of Aedes aegypti Breeding: A Novel Intervention for Prevention and Control of Dengue in an Endemic Zone of Delhi, India

Dengue, a fast spreading vector borne disease is endemic in more than 100 countries with half of world’s population living in area at risk of this disease... Read more »

Unravelling the Molecular Epidemiology and Genetic Diversity among Burkholderia pseudomallei Isolates from South India Using Multi-Locus Sequence Typing

Melioidosis, caused by soil saprophytic bacteria Burkholderia pseudomallei is a fatal infection among human and animals of the tropics. Numerous factors such as the... Read more »

Zika Virus Infection as a Cause of Congenital Brain Abnormalities and Guillain–Barré Syndrome: Systematic Review

An “explosive pandemic of Zika virus infection” in 2015 caught the world by surprise. The Pan American Health Organization and World Health Organization published an alert about a possible association with increases in reports of congenital abnormalities and Guillain–Barré syndrome... Read more »

Longitudinal Study of Transmission in Households with Visceral Leishmaniasis, Asymptomatic Infections and PKDL in Highly Endemic Villages in Bihar, India

Visceral leishmaniasis (VL), also known as kala-azar, is a neglected vector-borne disease caused by a protozoan parasite, Leishmania donovani and is transmitted by the... Read more »

Population Density, Climate Variables and Poverty Synergistically Structure Spatial Risk in Urban Malaria in India

The pronounced and on-going increase in urban population, combined with climate change and economic disparities could act synergistically on the transmission dynamics of malaria... Read more »

Longitudinal Study of Transmission in Households with Visceral Leishmaniasis, Asymptomatic Infections and PKDL in Highly Endemic Villages in Bihar, India

Visceral leishmaniasis, also known as kala-azar, is a neglected vector-borne disease caused by a protozoan parasite, Leishmania donovani and is transmitted by the bite of... Read more »

The Impact of Lymphatic Filariasis Mass Drug Administration Scaling Down on Soil-Transmitted Helminth Control in School-Age Children

Lymphatic filariasis and soil-transmitted helminth (STH) infections are co-endemic in 58 countries worldwide... Read more »

Immunotherapeutic Potential of Eugenol Emulsion in Experimental Visceral Leishmaniasis

Leishmaniasis, a complex vector-borne parasitic syndrome, is caused by obligate intra-macrophagic protozoan parasites of the genus Leishmania, a member of the order Kinetoplastida... Read more »

Noninvasive Diagnosis of Visceral Leishmaniasis: Development and Evaluation of Two Urine-Based Immunoassays for Detection of Leishmania donovani Infection in India

Visceral Leishmaniasis is a vector-borne fatal infectious disease disseminated in 88 countries of the world, particularly in remote areas of India, Bangladesh... Read more »

Typhoidal Salmonellae: Use of Multi-Locus Sequence Typing to Determine Population Structure

Enteric fever remains an important public health problem in developing countries. There are approximately 22 million typhoid cases and 2,16,510 deaths occur per year globally... Read more »

Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents

Leishmaniasis is a neglected tropical disease that is caused by the parasite ‘Leishmania’. Nearly 12 million people worldwide are affected by this disease... Read more »

Chronic Arsenic Exposure and Risk of Post Kala-azar Dermal Leishmaniasis Development in India: A Retrospective Cohort Study

Visceral Leishmaniasis is one of the neglected tropical diseases and a major global threat for health worldwide. It poses a major health problem in the poverty-ridden state of... Read more »

Prevalence of Latent Tuberculosis among Health Care Workers in High Burden Countries: A Systematic Review and Meta-Analysis

Health care workers (HCWs) are at increased risk of acquiring tuberculosis (TB) than the general population. The risk of TB in HCWs is of particular importance in the 22 high TB burden mostly low- and middle-income countries that... Read more »

The Tuberculosis Cascade of Care in India’s Public Sector: A Systematic Review and Meta-analysis

India has the world’s largest tuberculosis (TB) epidemic, with 23% of the global burden of incident active TB patients annually and 27% of the world’s “missing” patients, representing about 1 million patients each year who have not... Read more »

Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women

Neglected for a long time, P. vivax malaria is raising more attention lately due to the increased recognition of its burden and the renewed call for malaria elimination in endemic areas where P. vivax is an important source of... Read more »

Development, Validation, and Field-Testing of an Instrument for Clinical Assessment of HIV-Associated Neuropathy and Neuropathic Pain in Resource-Restricted and Large Population Study Settings

HIV-associated sensory peripheral neuropathy (HIV-SN) is a length-dependent distal symmetrical polyneuropathy that occurs in individuals with treated and untreated HIV infection... Read more »

Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process

Cholera is the most severe of all infectious diarrheal diseases, which if not adequately treated can have a high mortality up to 50%... Read more »

Prevalence and Identification of Burkholderia pseudomallei and Near-Neighbor Species in the Malabar Coastal Region of India

In India, melioidosis is considered as an emerging disease. Though melioidosis cases are considered to be significantly under-reported in India, few studies suggest that the disease is completely prevalent in India... Read more »
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