Infectious Disease Articles

Diagnostic Utility of a Line Probe Assay for Multidrug Resistant-TB in Smear-Negative Pulmonary Tuberculosis

Pulmonary tuberculosis is a major public health disease that ranks as the second-most leading cause of death worldwide, after human immunodeficiency virus infection. In 2016, there were 10.4 million new... Read more »

Prevalence and Associated Factors of Tuberculosis and Diabetes Mellitus Comorbidity: A Systematic Review

Diabetes mellitus and tuberculosis are major killers of mankind across the globe. The World Health Organization global report for 2015 indicates that, there were 10.4 million new cases and 1.4 million deaths resulting from... Read more »

Occult Hepatitis B Virus Infection in HIV Positive Patients at a Tertiary Healthcare Unit in Eastern India

Hepatitis B virus (HBV) infection continues to be a global health concern despite the presence of an effective vaccine. Worldwide, approximately 2 billion people have been infected with HBV at some stage of life, of them... Read more »

Field Evaluation of a Blood Based Test for Active Tuberculosis in Endemic Settings

Mycobacterium tuberculosis (M. tb.), the etiologic agent of tuberculosis, is one of the most successful human pathogens on the planet. Approximately two billion people are infected with M. tb. worldwide... Read more »

Suppression of Chikungunya Virus Replication and Differential Innate Responses of Human Peripheral Blood Mononuclear Cells During Co-Infection with Dengue Virus

Dengue virus currently causes the most prevalent arthropod-borne human disease. Chikungunya virus re-emerged in 2005–2006 with large outbreaks afflicting millions of people in the Indian Ocean areas and... Read more »

The impact of Glycemic Status on Radiological Manifestations of Pulmonary Tuberculosis in Diabetic Patients

Tuberculosis (TB) and diabetes mellitus (DM) are both important global health issues. In addition, the link between TB and DM has been demonstrated, and these conditions may complicate each other at... Read more »

Comparison of Monocyte Gene Expression Among Patients with Neurocysticercosis-Associated Epilepsy, Idiopathic Epilepsy and Idiopathic Headaches in India

Neurocysticercosis (NCC) is a brain infection by Taenia solium larvae which is a common cause of acquired epilepsy. NCC may consist of single or multiple larvae (cysts) that progress from viable vesicular to colloidal and granuloma states and finally... Read more »

Post-Dengue Acute Disseminated Encephalomyelitis: A Case Report and Meta-Analysis

Dengue, a worldwide prevalent mosquito-borne infectious disease, is a flavivirus spread by several species of Aedes type mosquitos, mainly Aedes aegypti. Dengue has become a dangerous burden and is widely spread in more than... Read more »

Candida Auris: A Rapidly Emerging Cause of Hospital-Acquired Multidrug-Resistant Fungal Infections Globally

Candidiasis, which includes both superficial infections and invasive disease, is the most common cause of fungal infection worldwide. Candida bloodstream infections (BSI) cause significant mortality and elicit a major threat to... Read more »

Burden and Impact of Plasmodium Vivax in Pregnancy: A Multi-Centre Prospective Observational Study

More than a third of the world′s population is at risk of Plasmodium vivax infection, 90% of whom live in the Asia and the Pacific regions, while the rest live in the American (6%) and African (3%) regions. In comparison with P. falciparum, P. vivax infection has received little attention mostly because it has been considered a relatively benign disease... Read more »

The microbiome composition of Aedes aegypti is not critical for Wolbachia-mediated inhibition of dengue virus

Dengue virus (DENV) is an RNA arbovirus and the causative agent of dengue fever and the more severe dengue haemorrhagic fever. There are four serotypes of DENV (DENV1-4), which together are estimated to infect 390 million people per year. Currently there are no... Read more »

Cost-Effectiveness of Hepatitis C Treatment Using Generic Direct-Acting Antivirals Available in India

Hepatitis C virus (HCV) infects more than 70 million people worldwide and between 6–11 million in India. Chronic HCV infection is the leading cause for cirrhosis, hepatocellular carcinoma and... Read more »

Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum

Depending on the geographical location, visceral leishmaniasis can either be caused by Leishmania donovani (East Africa and Indian subcontinent) or L. infantum (Mediterranean basin, central Asia and Latin America). Although both species are closely related and belong to the same complex (L. donovani complex), transmission of L. donovani is mostly anthroponotic while... Read more »

Cholera Forecast for Dhaka, Bangladesh, with the 2015-2016 El Niño: Lessons Learned

Climate variability, specifically the El Niño-Southern Oscillation, has been shown to influence the year-to-year variation of seasonal outbreaks of cholera in Bangladesh. In particular, interannual variations of the disease have been shown to be positively associated with... Read more »

Transcriptome analysis of mycobacteria in sputum samples of pulmonary tuberculosis patients

The success of Mycobacterium tuberculosis as a human pathogen is largely due to its ability to switch between latent and active states and to adapt to different environments and stresses. These adaptations are reflected by... Read more »

Interventions For Treating Patients With Chikungunya Virus Infection-Related Rheumatic and Musculoskeletal Disorders

Chikungunya virus infection is caused by an alphavirus transmitted by Aedes aegypti and Aedes albopictus mosquitoes. Three reports from the mid-1950s describe an outbreak of viral disease observed in... Read more »

Characterizing Antibody Responses to Plasmodium vivax and Plasmodium falciparum Antigens in India Using Genome-Scale Protein Microarrays

The burden of malaria in India has halved over the last 15 years, yet India continues to account for over 70% of malaria cases in South East Asia. The ‘National Framework for Malaria Elimination in India 2016–2030’ has two aims: eliminating malaria throughout the country by... Read more »
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