Impairment of Colour Vision in Diabetes with No Retinopathy

Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SNDREAMS- II, Report 3)

Citation: Gella L, Raman R, Kulothungan V, Pal SS, Ganesan S, Sharma T (2015) Impairment of Colour Vision in Diabetes with No Retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SNDREAMS- II, Report 3). PLoS ONE 10(6): e0129391. doi:10.1371/journal.pone.0129391
Published: June 8, 2015

Abstract
Purpose: To assess impairment of colour vision in type 2 diabetics with no diabetic retinopathy and elucidate associated risk factors in a population-based cross-sectional study.
Methods: This is part of Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular-genetics Study (SN-DREAMS II) which was conducted between 2007–2010. FM 100 hue-test was performed in 253 subjects with no clinical evidence of diabetic retinopathy. All subjects underwent detailed ophthalmic evaluation including cataract grading using LOCS III and 45° 4-field stereoscopic fundus photography. Various ocular and systemic risk factors for impairment of colour vision (ICV) were assessed in subjects with diabetes but no retinopathy. P value of < 0.05 was considered statistically significant.
Results: The mean age of the study sample was 57.08 ± 9.21 (range: 44–86 years). Gender adjusted prevalence of ICV among subjects with diabetes with no retinopathy was 39.5% (CI: 33.5–45.5). The mean total error score in the study sample was 197.77 ± 100 (range: 19–583). The risk factors for ICV in the study were women OR: 1.79 (1.00–3.18), increased resting heart rate OR: 1.04 (1.01–1.07) and increased intraocular pressure OR: 1.12 (1.00–1.24). Significant protective factor was serum high-density lipoprotein OR: 0.96 (0.93–0.99).
Conclusions: Acquired ICV is an early indicator of neurodegenerative changes in the retina. ICV found in diabetic subjects without retinopathy may be of non-vascular etiology.

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This entry was posted in Diabetes, Ophthalmology and tagged , .

One Comment

  1. jaspal ahluwalia
    Posted Sep 2015 at 3:54 pm | Permalink

    95% of retina is neural tissue & BV constitute only 5%.
    Neural tissue is very sensitive to the defficiency of lnsulin. & can get damaged as early as IGT stage whereas BV take many years for damage as microangiopathy
    .Multifocal ERG show an early reduction in amplitude.
    Suggesting damage to neural tissue without visible changes in retina with normal vision. Changes in color perception in early stages is suggestive of peripheral neuropathy of retina which is very responsive to early insulization & thus prevents the progression of DR.

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