Category Archives: Pharmacology

Pharmacology in the news as well as the latest learned articles and clinical research related to medicines, their efficacy and usages in the treatment of health conditions and disease.

Pregabalin found more effective than pramipexole in restless leg syndrome

mdCurrent Conference Report: 64th American Academy of Neurology Annual Meeting A major multicenter study undertaken in restless leg syndrome (RLS) demonstrated greater efficacy for the alpha-2-delta ligand pregabalin than the dopamine agonist pramipexole, which has been widely regarded until now as the first-line treatment. In the study, presented at the… 

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New migraine guidelines focus on efficacy, prevention, and patient-centric approach

mdCurrent Conference Report: 64th American Academy of Neurology Annual Meeting A large number of therapies are used prophylactically to prevent or abort migraine headaches but only 7 have proven efficacy, according to newly released guidelines. The authors of the guidelines, issued jointly by the American Academy of Neurology (AAN) and… 

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Macrolide antibacterial agent fidaxomicin may be an alternative to vancomycin for Clostridium difficile-associated diarrhea

Fidaxomicin, a macrolide antibiotic, is noninferior to vancomycin in the treatment of Clostridium difficile diarrhea in terms of clinical cure. This was the main finding of a recent randomized trial that sought to demonstrate the noninferiority of fidaxomicin for this indication. C difficile, which causes 15% to 25% of antibiotic-associated… 

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Also posted in Gastroenterology, Infectious Disease, Primary Care | Tagged , , , , , , , , | Volume: | Leave a comment

Adding metformin to insulin therapy in patients with type 2 diabetes does not impact long-term outcomes

The addition of metformin to insulin therapy in patients with type 2 diabetes does not significantly impact all-cause or cardiovascular mortality, although the combination reduced hemoglobin A1C values, weight gain, and insulin doses, a recent study found. Combining metformin to insulin also may increase the risk of hypoglycemia. According to… 

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Also posted in Diabetes, Non-Communicable Disease, Primary Care | Tagged , , , , , , , , | Volume: | Leave a comment

Protection against Parkinson disease could be an added benefit of statins

An added benefit from statin use appears to be a slightly lower risk of Parkinson disease (PD), according to an analysis of 2 large prospective cohorts. Key Point: Statin use may offer moderate protection against the development of Parkinson disease, but further studies are needed to confirm this association. The… 

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Estrogen-only hormone therapy reduces invasive breast cancer risk after hysterectomy

Estrogen alone after a hysterectomy reduces the risk of invasive breast cancer, according to a follow-up analysis of postmenopausal women enrolled in the U.S. Women’s Health Initiative (WHI) study. In the WHI study, women aged 50 to 79 years who had undergone hysterectomy were randomized to receive estrogen alone (0.625… 

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Using checklist helps to prevent heart failure readmissions

mdCurrent Conference Report: American College of Cardiology’s 61st Annual Scientific Session & Expo Completing a simple 1-page checklist before discharging heart failure patients goes a long way toward reducing the number of hospital readmissions. The checklist, developed by Abhijeet Basoor, MD, a fellow in cardiovascular medicine at St. Joseph Mercy… 

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