Category Archives: Pharmacology

Pharmacology in the news as well as the latest learned articles and clinical research related to medicines, their efficacy and usages in the treatment of health conditions and disease.

Thrombolysis may be beneficial later and in older patients suffering an acute stroke

About 1.44 to 1.64 million cases of new stroke occur each year in India, with stroke sufferers losing over 6 million disability-adjusted life years (DALYs) annually due to death and disability, according to data from the World Health Organization (WHO). Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is used to… 

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Also posted in Geriatrics, Neurology, Neurology Featured 2, Non-Communicable Disease, Primary Care | Tagged , , , , , , , , , | Volume: | Leave a comment

Even infrequent use of hypnotics may increase mortality risk

Taking hypnotic drugs, even sporadically, may increase the risk of death, a recent study has found. Researchers at the Scripps Clinic Sleep Center in La Jolla, California, United States, estimated the mortality risk of hypnotics in 10,529 adults who received hypnotic prescriptions and 23,676 matched controls; the subjects were followed… 

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Also posted in Neurology, Neurology Featured 2, Primary Care | Tagged , , , , , | Volume: | Leave a comment

Meta-analyses: Aspirin’s utility in chronic kidney disease isn’t clear

An increase in the risk of bleeding may nullify the benefits of antiplatelet therapy in patients with chronic kidney disease (CKD), according to a pair of meta-analyses. The evidence from clinical trials included in the meta-analyses is of low quality, the authors reported, with numerous limitations. “Bleeding hazards and lack… 

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Also posted in Cardiovascular Disease, Diabetes, Nephrology, Primary Care | Tagged , , , , , , , , | Volume: | Leave a comment

Early therapy delays progression to clinically definite multiple sclerosis

mdCurrent Conference Report: 64th American Academy of Neurology Annual Meeting Data from 2 major phase 3 trials have demonstrated that progression to clinically definite multiple sclerosis (MS) can be prevented or delayed with early rather than delayed therapy. Two regimens of subcutaneous interferon beta-1a (IFNb) were evaluated in patients who… 

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Also posted in mdCurrent Conference Reports, Neurology | Tagged , , , , , , , , , , | Volume: | Leave a comment

Continuous intestinal infusion of levodopa-carbidopa gel shows benefit in advanced Parkinson’s disease

mdCurrent Conference Report: 64th American Academy of Neurology Annual Meeting A novel strategy to reduce the motor complications associated with fluctuating blood levels of levodopa in patients with Parkinson’s disease was associated with clinically meaningful improvements in disease control, according to the authors of a double-blind trial. Undertaken in patients… 

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First oral disease modifying therapy for multiple sclerosis challenges injectables in long-term data

mdCurrent Conference Report: 64th American Academy of Neurology Annual Meeting Follow-up data out to 24 months for the first oral disease modifying therapy (DMT) licensed for treatment of multiple sclerosis (MS) continues to suggest that the efficacy and safety rivals that of the injectable agents that have been the MS… 

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Regular aspirin use may reduce risk of cancer metastasis

Daily aspirin may prevent distant cancer metastasis, according to a recent analysis. Researchers from the United Kingdom examined 5 large, randomized trials (17,285 participants) of daily aspirin (≥75 mg daily) vs control for the prevention of vascular events to assess the effect of aspirin on the frequency of distant metastasis… 

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Also posted in Non-Communicable Disease, Oncology, Primary Care | Tagged , , , , , , , | Volume: | Leave a comment