Category Archives: Pharmacology

Pharmacology in the news as well as the latest learned articles and clinical research related to medicines, their efficacy and usages in the treatment of health conditions and disease.

Blanket prescribing of beta-blockers to all patients with CAD or at risk of CAD does not reduce cardiovascular risk

Beta-blocker therapy is not associated with a lower risk of death, nonfatal myocardial infarction (MI), and nonfatal stroke in patients with coronary artery disease (CAD) risk factors, known CAD without MI, or prior MI, according to a recent observational study. “…Trends are changing, and the evidence is compelling to use… 

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Risk of postnatal fever with misoprostol linked to dosage, administration route

The prostaglandin E1 analog misoprostol is widely used to prevent postpartum hemorrhage, which is the leading cause of maternal death in India. Misoprostol is especially practical in low-resource settings because of its efficacy, cost-effectiveness, and ease of administration (sublingual, oral, vaginal, or rectal). It’s also not heat labile, which makes… 

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New-generation anticoagulant agents pose risks in treatment of acute coronary syndromes

The potential ischemic benefits of novel oral antiplatelet therapy following an acute coronary syndrome (ACS) may be offset by a significant increase in major bleeding events, according to a meta-analysis recently published in the Archives of Internal Medicine. “We are already exposing these patients to several drugs that can produce… 

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Elderly hypertensive patients with cardiovascular disease may benefit from combination antihypertensive therapy

Adding a second antihypertensive medication appears to be more beneficial than increasing the dose of a single antihypertensive in reducing all-cause mortality cardiovascular outcomes in patients with cardiovascular disease (CVD). This was the main finding of a recent randomized trial that sought to determine the efficacy of high-dose angiotensin receptor… 

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Delamanid may be beneficial as an add-on therapy to the standard treatment regimen of multidrug resistant tuberculosis

The investigational antibiotic delamanid increased 2-month sputum-culture conversion in patients with multidrug-resistant pulmonary tuberculosis (TB). This was the main finding of a recent randomized, placebo-controlled trial that sought to determine the efficacy and safety of delamanid added to standard therapy vs standard therapy alone in this population. Key Point: Delamanid,… 

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Type 2 diabetes treated with insulin increases lung cancer risk in postmenopausal women

Postmenopausal women with type 2 diabetes that requires treatment with insulin demonstrated an increased risk for developing lung cancer, according to an analysis of the Women’s Health Initiative (WHI) study. “Physicians in India should screen diabetes patients, especially women, for lung cancer, particularly those on insulin therapy.” -Vijay Viswanathan, MD,… 

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Diabetic neuropathy may be linked to metabolic risk factors

Neuropathy is a common, disabling complication of diabetes, and its incidence in India is growing as the prevalence of diabetes—especially type 2 diabetes—continues to rise nationally. India has the world’s largest diabetic population, with an estimated 62 million people diagnosed with the condition, according to the Indian Council of Medical… 

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