Category Archives: Infectious Disease

The list of infectious diseases which occur with significant frequency in India is long and alarming. It is in the interest of local doctors and clinicians to stay abreast of international news and research on the diagnosis and treatment of infectious diseases such as bacterial diarrhea, hepatitis A and E, typhoid fever, chikungunya, dengue fever, yellow fever Japanese encephalitis, malaria, rabies and leptospirosis

Macrolide antibacterial agent fidaxomicin may be an alternative to vancomycin for Clostridium difficile-associated diarrhea

Fidaxomicin, a macrolide antibiotic, is noninferior to vancomycin in the treatment of Clostridium difficile diarrhea in terms of clinical cure. This was the main finding of a recent randomized trial that sought to demonstrate the noninferiority of fidaxomicin for this indication. C difficile, which causes 15% to 25% of antibiotic-associated… 

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Also posted in Gastroenterology, Pharmacology, Primary Care | Tagged , , , , , , , , | Volume: | Leave a comment

Statin therapy has modest effect in preventing pneumonia

Statin therapy may modestly reduce the risk of pneumonia in healthy adults, researchers have found in a subanalysis of the JUPITER study. Key Point: This study offers support for the continued research of statin therapy in the prevention of infection, including lung infection. The use of statins, the first-line therapy… 

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Also posted in Cardiovascular Disease, Pharmacology | Tagged , , , , , , , , | Volume: | Leave a comment

New dengue fever classification differentiates typical and severe infections to improve patient triage and management

The spread of dengue fever is a significant problem, mostly due to increased global trade and travel. It is estimated to cause 50 million infections yearly, with outbreaks in India becoming more commonplace. Infections often occur in urban areas and spread into neighboring communities. Over the last 20 years, higher… 

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Also posted in Primary Care | Tagged , , , , , | Volume: | Leave a comment

Benefits outweigh the risks for antimalarial treatment of women in the first trimester of pregnancy

Malaria caused by either Plasmodium vivax or Plasmodium falciparum increases miscarriage risk during the first trimester. Antimalarial treatment is important and chloroquine, quinine, and mefloquine do not significantly increase the risk of miscarriage or other adverse events, according to a population-based study. “This paper confirms the dictum that malaria in… 

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Also posted in Ob/Gyn | Tagged , , , , , , , , | Volume: | 1 Response

Treat tuberculosis in pregnancy using first-line agents, but wait for second-line agents

Beware of false-positive skin tests in pregnant women vaccinated with BCG (Bacille Calmette Guerin vaccine for tuberculosis [TB]), in those previously treated for TB infection, or in those previously infected with other Mycobacterium species. False negatives can occur in those with compromised immune systems (eg, HIV) or due to technical… 

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Also posted in Ob/Gyn, Pharmacology | Tagged , , , , , , , , , , , , , , , , , , , , | Volume: | 1 Response

Antiviral therapy may not be enough to suppress genital herpes reactivation

Even high-dose antiherpetic therapy may not be enough to quell short bursts of subclinical genital herpes simplex virus (HSV) reactivation, which may account for the continued transmission of HSV despite suppressive antiviral therapy. Researchers from the University of Washington, Seattle, United States, conducted 3 separate but complementary open-label crossover studies… 

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Also posted in Ob/Gyn, Pharmacology, Primary Care, Urology | Tagged , , , , , , , , , , , , | Volume: | Leave a comment

New neurological complications emerging in dengue fever

A retrospective study conducted over 2 years in a tertiary center in Northern India has taken a closer look at neurological complications that are occurring with increasing frequency in dengue infection. “Initially, dengue was not considered neurotropic. However, enough evidence has accumulated to call it a neurotropic or neuroinvasive virus.”… 

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Also posted in Neurology, Primary Care | Tagged , , , , , , , | Volume: | 1 Response