Category Archives: Infectious Disease Featured 1

MDR-TB Treatment as Prevention: The Projected Population-Level Impact of Expanded Treatment for Multidrug-Resistant Tuberculosis

Multidrug resistant tuberculosis (MDR-TB) poses one of the greatest threats to TB control worldwide. Not only is the incidence of MDR-TB rising in many areas, curtailing…

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Estimating the Burden of Scrub Typhus: A Systematic Review

Scrub typhus is an infectious disease caused by Orientia tsutsugamushi, an obligate intracellular bacteria, transmitted by the bites of chigger mites…

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Health Impact and Cost-Effectiveness of a Domestically-Produced Rotavirus Vaccine in India: A Model Based Analysis

Each year, rotavirus gastroenteritis claims the lives of an estimated 215,000 children under five years of age; 22% of these deaths are estimated to…

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Safety and Efficacy of Short Course Combination Regimens with AmBisome, Miltefosine and Paromomycin for the Treatment of Visceral Leishmaniasis in Bangladesh

Before the introduction of single-dose AmBisome, miltefosine was included in the National Guidelines of India, Nepal and Bangladesh as a first line treatment for VL following a phase III trial in India that showed a final cure rate of 94%. However, poor compliance due to…

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Diagnostic Utility of a Line Probe Assay for Multidrug Resistant-TB in Smear-Negative Pulmonary Tuberculosis

Pulmonary tuberculosis is a major public health disease that ranks as the second-most leading cause of death worldwide, after human immunodeficiency virus infection. In 2016, there were 10.4 million new…

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Comorbidities in Pulmonary Tuberculosis Cases in Puducherry and Tamil Nadu, India: Opportunities for Intervention

An estimated 10.6 million cases of tuberculosis (TB) occur annually in the world, and India accounts for 27% of these. The emergence of drug-resistant TB creates a renewed sense of urgency to control…

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Identification of Burden Hotspots and Risk Factors for Cholera in India: An Observational Study

Cholera has existed in India for centuries, and is an important public health problem in several parts of the country.. Based on a ten year review from 1997 to 2006, 21 states reported cholera and 12 had multiple outbreaks. During the 10-year period studied, the states having the highest number of…

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