Category Archives: Infectious Disease Featured 1

Breast Tuberculosis in Men: A Systematic Review

Tuberculosis is a chronic granulomatous inflammation usually involving the lung parenchyma and hilar lymph nodes. Extra-pulmonary involvement is seen in…

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Towards Elimination of Visceral Leishmaniasis in the Indian Subcontinent—Translating Research to Practice to Public Health

About 147 million people are at risk of visceral leishmaniasis, in the Southeast Asian region. The largely localized geographic endemicity, anthroponotic transmission with humans as the only host reservoir, the sandfly species Phlebotomous argentipes as the only vector species, and the…

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MDR-TB Treatment as Prevention: The Projected Population-Level Impact of Expanded Treatment for Multidrug-Resistant Tuberculosis

Multidrug resistant tuberculosis (MDR-TB) poses one of the greatest threats to TB control worldwide. Not only is the incidence of MDR-TB rising in many areas, curtailing…

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Estimating the Burden of Scrub Typhus: A Systematic Review

Scrub typhus is an infectious disease caused by Orientia tsutsugamushi, an obligate intracellular bacteria, transmitted by the bites of chigger mites…

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Health Impact and Cost-Effectiveness of a Domestically-Produced Rotavirus Vaccine in India: A Model Based Analysis

Each year, rotavirus gastroenteritis claims the lives of an estimated 215,000 children under five years of age; 22% of these deaths are estimated to…

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Safety and Efficacy of Short Course Combination Regimens with AmBisome, Miltefosine and Paromomycin for the Treatment of Visceral Leishmaniasis in Bangladesh

Before the introduction of single-dose AmBisome, miltefosine was included in the National Guidelines of India, Nepal and Bangladesh as a first line treatment for VL following a phase III trial in India that showed a final cure rate of 94%. However, poor compliance due to…

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Diagnostic Utility of a Line Probe Assay for Multidrug Resistant-TB in Smear-Negative Pulmonary Tuberculosis

Pulmonary tuberculosis is a major public health disease that ranks as the second-most leading cause of death worldwide, after human immunodeficiency virus infection. In 2016, there were 10.4 million new…

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