Monthly Archives: August 2017

Burden and Impact of Plasmodium Vivax in Pregnancy: A Multi-Centre Prospective Observational Study

More than a third of the world′s population is at risk of Plasmodium vivax infection, 90% of whom live in the Asia and the Pacific regions, while the rest live in the American (6%) and African (3%) regions. In comparison with P. falciparum, P. vivax infection has received little attention mostly because it has been considered a relatively benign disease…

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Patients with Subclinical Hypothyroidism Before 20 Weeks of Pregnancy have a Higher Risk of Miscarriage

Thyroid dysfunction is prevalent in pregnant women, with a morbidity of 2–3%; it is always caused by chronic autoimmune thyroiditis. Moreover, 5–15% women of reproductive age are diagnosed with thyroid autoimmunity, leading to high risk of adverse pregnancy outcomes…

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Painless Swelling of the Forefoot and Recurrent Subcutaneous Abscesses of the Lower Leg—Two Distinct Presentations Illustrating the Spectrum of Eumycetoma in a Nonendemic Country

Eumycetoma is a neglected tropical disease that is characterized by chronic progressive local inflammation of subcutaneous tissues with sinus formation and purulent discharge. Although the infection evolves from a small subcutaneous nodule, patients often present late with advanced disease, including…

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An Individual-Level Meta-Analysis Assessing the Impact of Community-Level Sanitation Access on Child Stunting, Anemia, and Diarrhea

An estimated 1 billion people live without access to any type of sanitation facility, i.e. a toilet or latrine. This lack of sanitation access fails to contain human feces, which are responsible for transmission of various diarrheal diseases as well as…

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The microbiome composition of Aedes aegypti is not critical for Wolbachia-mediated inhibition of dengue virus

Dengue virus (DENV) is an RNA arbovirus and the causative agent of dengue fever and the more severe dengue haemorrhagic fever. There are four serotypes of DENV (DENV1-4), which together are estimated to infect 390 million people per year. Currently there are no…

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Cost-Effectiveness of Hepatitis C Treatment Using Generic Direct-Acting Antivirals Available in India

Hepatitis C virus (HCV) infects more than 70 million people worldwide and between 6–11 million in India. Chronic HCV infection is the leading cause for cirrhosis, hepatocellular carcinoma and…

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Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum

Depending on the geographical location, visceral leishmaniasis can either be caused by Leishmania donovani (East Africa and Indian subcontinent) or L. infantum (Mediterranean basin, central Asia and Latin America). Although both species are closely related and belong to the same complex (L. donovani complex), transmission of L. donovani is mostly anthroponotic while…

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