Monthly Archives: September 2016

Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm

Visceral leishmaniasis caused by the species Leishmania donovani, is the most severe form of leishmaniasis and is endemic in the region of Indian subcontinent. Due to its digenic …

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PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide

PI3K is crucial signal transducing enzyme regulating cell proliferation, cell survival, differentiation, apoptosis and angiogenesis. It is essential for activation of AKT which plays a central role in both physiological and…

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Mycobacterium tuberculosis DevR/DosR Dormancy Regulator Activation Mechanism

Two component systems permit bacteria to sense and adapt to diverse environmental stresses. The DevR-DevS TCS (also called DosR-DosS) is one of the best characterized TCS of Mycobacterium tuberculosis…

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Visceral Leishmaniasis on the Indian Subcontinent: Modelling the Dynamic Relationship between Vector Control Schemes and Vector Life Cycles

The deadliest form of leishmaniasis, visceral leishmaniasis, is vector-transmitted through the bite of phlebotomine sand flies in the Phlebotomus and Lutzomyia genera…

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Sensitivity Analysis and Optimal Control of Anthroponotic Cutaneous Leishmania

Anthroponotic cutaneous leishmaniasis (ACL) is an infectious disease caused by Leishmina Tropica. The parasite is transmitted by the sand fly…

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Is There a Need for Viral Load Testing to Assess Treatment Failure in HIV-Infected Patients Who Are about to Change to Tenofovir-Based First-Line Antiretroviral Therapy?

Both the 2010 and 2013 WHO Guidelines on the use of antiretroviral drugs for treating and preventing HIV infection have emphasized a) the phasing out of stavudine (d4T) and replacement with tenofovir…

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Establishment of 3D Co-Culture Models from Different Stages of Human Tongue Tumorigenesis: Utility in Understanding Neoplastic Progression

All normal tissues rely on a continuous sequence of cellular interactions in a microenvironment comprising several growth factors, hormones, adhesion molecules and an intricate extracellular molecular matrix for their growth and maintenance…

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